Research

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Inflamación
Instituto Nacional sobre el Abuso de Drogas (NIDA)
Interacciones Farmacológicas
Isquemia

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R

Adicción

• Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats
• Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances
• Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence
• Cannabis as a substitute for alcohol and other drugs
• Interactions between delta9-tetrahydrocannabinol and heroin: self-administration in rhesus monkeys
• Medical Cannabis Laws and Opioid Analgesic Overdose Mortality in the United States, 1999-2010

Alzheimer / Demencia

• A Molecular Link Between the Active Component of Marijuana and Alzheimer’s Disease Pathology
• Amyloid-beta inhibits E-S Potentiation through suppression of cannabinoid receptor 1-dependent synaptic disinhibition
• Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids
• Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer’s disease
• Alzheimer’s disease; taking the edge off with cannabinoids?
• Cannabinoids and Dementia: A Review of Clinical and Preclinical Data
• Cannabinoids and Parkinson’s disease
• Cannabinoids for the treatment of agitation and aggression in Alzheimer’s disease
• Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic
• Cannabinoids for the treatment of dementia
• Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer’s disease
• CB2 Cannabinoid Receptor As Potential Target against Alzheimer’s Disease
• Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1∆E9 mice
• Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia
• Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview
• Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
• Prevention of Alzheimer’s disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation
• Safety and efficacy of medical cannabis oil for behavioral and psychological symptoms of dementia: An-open label, add-on, pilot study
• Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer’s disease
• Synthetic cannabinoids in dementia with agitation: Case studies and literature review
• The influence of cannabinoids on generic traits of neurodegeneration
• The potential therapeutic effects of THC on Alzheimer’s disease
• The role of the endocannabinoid signaling in the molecular mechanisms of neurodegeneration in Alzheimer’s disease

Esclerosis Lateral Amiotrófica

• Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid
• Cannabinol delays symptom onset in SOD1 transgenic mice without affecting survival
• Cannabis and amyotrophic lateral sclerosis
• Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials
• Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice
• Neurological aspects of medical use of CBD
• Self-medication with cannabidiol oil in a patient with primary lateral sclerosis
• Survey of cannabis use in patients with amyotrophic lateral sclerosis

Anorexia

• Cannabidiol Attenuates the Appetitive Effects of Δ₉-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis
• Changes in IGF-I, urinary free cortisol and adipokines during dronabinol therapy in anorexia nervosa: Results from a randomised, controlled trial
• Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS
• Dronabinol in severe, enduring anorexia nervosa: a randomized controlled trial
• Effect of dronabinol therapy on physical activity in anorexia nervosa: a randomised, controlled trial
• Endocannabinoids, feedling and suckling – from our perspective
• Endogenous cannabinoid system as a modulator of food intake
• Hypothalamic POMC neurons promote cannabinoid-induced feeding
• The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection
• The role of the endocannabinoid system in eating disorders: neurochemical and behavioural preclinical evidence

Antibacterial

• Antibacterial Cannabinoids from Cannabis sativa: A Structure-Activity Study
• Antimicrobial Activity of Cannabis sativa L.
• Extraction of cannabinoids from cannabis sativa L plant and its potential antimicrobial activity
• In vitro antibacterial activity of Cannabis sativa leaf extracts to some selective pathogenicbacterial strains
• Marijuana, Tetrahydrocannabinol, and Pulmonary Antibacterial Defenses

Antioxidante

• Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
• * Mechanism for inhibitory effect of cannabidiol on microsomal testosterone oxidation in male rat liver
• Oxyradical Stress, Endocannabinoids, and Atherosclerosis
• Prospects for cannabinoid therapies in basal ganglia disorders

Antiprión

• Nonpsychoactive Cannabidiol Prevents Prion Accumulation and Protects Neurons against Prion Toxicity

Ansiedad

• Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects
• Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa
• Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug
• Cannabidiol as a Potential Treatment for Anxiety Disorders
• Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients
• Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders
• Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives
• Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation
• Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors
• Effects of Cannabidiol (CBD) on Regional Cerebral Blood
• Effects of ipsapirone and cannabidiol on human experimental anxiety
• Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing
• Medical cannabis and mental health: A guided systematic review
• Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report
• Overexpression of CB2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice
• Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence
• Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors
• The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system

Apetito

• Cannabidiol Attenuates the Appetitive Effects of Δ₉-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis
• Endocannabinoids, feeding and suckling – from our perspective
• Endogenous cannabinoid system as a modulator of food intake
• Hypothalamic POMC neurons promote cannabinoid-induced feeding

Malformación de Arnold-Chiari

• A survey of cannabis (marijuana) use and self-reported benefit in men with chronic prostatitis/chronic pelvic pain syndrome
• Cannabinoids and multiple sclerosis
• Cannabis use for chronic non-cancer pain: results of a prospective survey
• Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache: What a Long Strange Trip It’s Been…
• Delta-9-tetrahydrocannabinol-cannabidiol (Sativex): a review of its use in patients with moderate to severe spasticity due to multiple sclerosis
• Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence

Artritis

• A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis
• Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint
• Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees
• Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
• Cannabinoid WIN‑55,212‑2 mesylate inhibits ADAMTS‑4 activity in human osteoarthritic articular chondrocytes by inhibiting expression of syndecan‑1
• Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1b induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression in human chondrocytes
• Characterisation of the Cannabinoid Receptor System in Synovial Tissue and Fluid in Patients With Osteoarthritis and Rheumatoid Arthritis
• * Involvement of the endocannabinoid system in osteoarthritis pain
• Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis
• Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717
• The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis

Asma

• The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke
• Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma
• Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs
• Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways
• Bronchodilator effect of delta1-tetrahydrocannabinol
• Evaluation of serum cytokines levels and the role of CBD treatment in animal model of asthma

Trastorno por Déficit de Atención e Hiperactividad (TDAH)

• Association of the Cannabinoid Receptor Gene (CNR1) With ADHD and Post-Traumatic Stress Disorder
• Cannabis improves symptoms of ADHD
• * Cannabinoid-induced conditioned place preference in the spontaneously hypertensive rat–an animal model of attention deficit hyperactivity disorder
• Drug Reinforcement in a Rat Model of Attention Deficit-Hyperactivity Disorder – The Spontaneously Hypertensive Rat (SHR)

Autismo

• A novel approach to the symptomatic treatment of autism
• Alternations in the endocannabinoid system in the rat valproic acid model of autism
• Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling
• Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems—A Retrospective Feasibility Study
• Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders
• Consequences of cannabinoid and monoaminergic system disruption in a mouse model of autism spectrum disorders
• Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling
• Deficient Social and Play Behavior in Juvenile and Adult Rats after Neonatal Cortical Lesion: Effects of Chronic Pubertal Cannabinoid Treatment
• Endocannabinoid Signaling in Autism
• Endocannabinoid System as Novel Therapeutic Target for Autism Treatment
• Method for predicting autism spectrum disorders by cannabinoid and cannabinoid receptor expression
• Mutations found in individuals with autism interfere with endocannabinoid signaling in the brain
• Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands
• Targeting the endocannabinoid system in the treatment of fragile X syndrome
• The Endocannabinoid System and Autism Spectrum Disorders: Insights from Animal Models
• Uncoupling of the endocannabinoid signaling complex in a mouse model of fragile X syndrome
• Use of dronabinol (delta-9-THC) in autism: A prospective single-case-study with an early infantile autistic child
• Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces

Autoinmune

• Cannabidiol Arrests Onset of Autoimmune Diabetes in NOD Mice
• Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol

Disfunción Autonómica

• Blurred Boundaries: The Therapeutics and Politics of Medical Marijuana
• Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs
• Cannabinoid CB2 receptor activation attenuates motor and autonomic function deficits in a mouse model of spinal cord injury
• * Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis
• Cannabinoid pharmacology: the first 66 years
• Cannabinoid Receptor 2 Signaling in Neurodegenerative Disorders: From Pathogenesis to a Promising Therapeutic Target
• * Cannabinoids and experimental models of multiple sclerosis
• Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta
• Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries
• Effects of cannabinoids on sympathetic and parasympathetic neuroeffector transmission in the rabbit heart
• Endocannabinoids Acting at Cannabinoid-1 Receptors Regulate Cardiovascular Function in Hypertension
• Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
• * The endocannabinoid system and its therapeutic exploitation
• The endocannabinoid system as an emerging target of pharmacotherapy
• Vascular targets for cannabinoids: animal and human studies

Enfermedad de Batten

• Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
• Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study
• siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycineinduced cell migration

Presión Arterial

• A systematic review and meta-analysis of the haemodynamic effects of cannabidiol
• A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study
• Blood pressure regulation by endocannabinoids and their receptors
• Is the cardiovascular system a therapeutic target for cannabidiol?
• * Safety and side effects of cannabidiol, a cannabis sativa constituent

Salud Ósea

• Activation of cannabinoid receptor 2 enhances osteogenic differentiation of bone marrow derived from mesenchymal stem cells
• Cannabidiol, a Major Non-Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts
• Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro
• Cannabinoids and the skeleton: from marijuana to reversal of bone loss
• Cannabinoid receptors and the regulation of bone mass
• Mechanical and material properties of cortical and trabecular bone from cannabinoid receptor-1-null (Cnr1(-/-)) mice
• Peripheral cannabinoid receptor, CB2, regulates bone mass
• Protective Effects of Cannabidiol on Lesion-Induced Intervertebral Disc Degeneration
• Role of cannabinoids in the regulation of bone remodeling
• * The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling

Cáncer de Mama

• Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
• *Cannabidiolic acid-mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressiveness
• Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
• Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy
• *Cannabinoids: A new hope for breast cancer therapy?
• Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
• Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells
• Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent
• Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
• Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer
• Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer
• The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation

Cachexia (Sindrome de Desgaste)

• Cannabidiol Attenuates the Appetitive Effects of Δ₉-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis
• * Cannabinoids in the treatment of the cachexia-anorexia syndrome in palliative care patients
• Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial
• Cannabis use in HIV for pain and other medical symptoms
• Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS
• Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: a North Central Cancer Treatment Group study
• * Effect of dronabinol therapy on physical activity in anorexia nervosa: a randomised, controlled trial
• Endocannabinoids, feeding and sucking – from our perspective
• Endogenous cannabinoid system as a modulator of food intake
• Hypothalamic POMC neurons promote cannabinoid-induced feeding
• The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection

Cáncer

• A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells
• A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
• Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors
• Antiangiogenic activity of the endocannabinoid anandamide: Correlation to its tumor-suppressor efficacy
• Anticancer effects of phytocannabinoids used with chemotherapy in leukaemia cells can be improved by altering the sequence of their administration
• Anticancer mechanisms of cannabinoids
• Antiemetic Effect of Delta-9-Tetrahydrocannabinol in Patients Receiving Cancer Chemotherapy
• Anti-proliferative effects of anandamide in human hepatocellular carcinoma cells
• Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy
• Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
• Antitumorigenic Effects of Cannabinoids beyond Apoptosis
• Association between cannabis use and the risk of bladder cancer: results from the California Men’s Health Study
• Cannabidiol (CBD) Priming Enhances Cisplatin Killing Of Cancer Cells
• Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
• Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
• Cannabidiol as potential anticancer drug
• Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
• Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy
• Cannabidiol inhibits angiogenesis by multiple mechanisms
• Cannabidiol Inhibits Cancer Cell Invasion Via Upregulation Of Tissue Inhibitor Of Matrix Metalloproteinases-1
• Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
• Cannabidiol Inhibits Growth and Induces Programmed Cell Death in Kaposi Sarcoma–Associated Herpesvirus Infected Endothelium
• Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1
• Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy
• Cannabidiolic acid-mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressiveness
• Cannabinoid-associated cell death mechanisms in tumor models (Review)
• Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma
• Cannabinoid Receptor Agonist as an Alternative Drug in 5-Fluorouracil-resistant Gastric Cancer Cells
• Cannabinoid receptor ligands as potential anticancer agents – high hopes for new therapies
• Cannabinoid Receptor-Mediated Apoptosis Induced by R()-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma
• Cannabinoid receptors as novel targets for the treatment of melanoma
• Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis
• Cannabinoids: A new hope for breast cancer therapy?
• Cannabinoids and cancer
• Cannabinoids and cancer: potential for colorectal cancer therapy
• Cannabinoids and cancer: pros and cons of an antitumour strategy
• Cannabinoids and ceramide: two lipids acting hand-by-hand
• Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators
• Cannabinoids as therapeutic agents in cancer: current status and future implications
• Cannabinoids, Endocannabinoids and Cancer
• Cannabinoids for Cancer Treatment: Progress and Promise
• Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
• Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas
• Cannabinoids in the treatment of the cachexia-anorexia syndrome in palliative care patients
• Cannabinoids: potential antitumoral agents?
• Cannabinoids: potential anticancer agents
• Cannabinoids Protect Astrocytes from Ceramide-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway
• Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
• Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells
• Cannabis and Cannabinoids (PDQ®) – National Cancer Institute | Patient
• Cannabis and Cannabinoids (PDQ®) – National Cancer Institute | Healthcare Professional
• Cannabis in cancer care
• Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation
• CBD inhibits angiogenesis by multiple mechanisms
• Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
• Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions
• Comparison of Orally Administered Cannabis Extract and Delta-9-Tetrahydrocannabinol in Treating Patients With Cancer-Related Anorexia-Cachexia Syndrome: A Multicenter, Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial From the Cannabis-In-Cachexia-Study-Group
• COX-2 and PPAR-g Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells
• Delta-9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
• Delta-9-tetrahydrocannabinol interferes with the establishment and the expression of conditioned rejection reactions produced by cyclophosphamide: a rat model of nausea
• Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized-double-blind, placebo-controlled pilot trial
• Differential role of cannabinoids in the pathogenesis of skin cancer
• Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells
• Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: a North Central Cancer Treatment Group study
• Endocannabinoids and Cancer
• Endocannabinoids and fatty acid amides in cancer inflammation and related disorders
• Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (Review)
• Endocannabinoids as Guardians of Metastasis
• Endocannabinoids in endocrine and related tumours
• Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedules
• Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa
• Exogenous hepatitis B virus envelope proteins induce endoplasmic reticulum stress: involvement of cannabinoid axis in liver cancer cells
• Expression and Functional Relevance of Cannabinoid Receptor 1 in Hodgkin Lymphoma
• Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: Growth inhibition by receptor activation
• High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma
• Id-1 Is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target
• Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor
• In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma
• Increasing Antiproliferative Properties of Endocannabinoids in N1E-115 Neuroblastoma Cells through Inhibition of Their Metabolism
• Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1
• Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
• Inhibition of tumor angiogenesis by cannabinoids
• Integrating cannabis into clinical cancer care
• Involvement of PPARc in the antitumoral action of cannabinoids on hepatocellular carcinoma
• Loss of Cannabinoid Receptor 1 Accelerates Intestinal Tumor Growth
• Marijuana Use and the Risk of Lung and Upper Aerodigestive Tract Cancers: Results of a Population-Based Case-Control Study
• Medical marijuana for cancer
• Medical Marijuana Use in Oncology
• Microarray and Pathway Analysis Reveal Distinct Mechanisms Underlying Cannabinoid-Mediated
• Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent
• Modulation of LPS-Induced Activation of BV-2 Microglial Cells
• Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC: CBD extract and THC extract in patients with intractable cancer-related pain
• Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms
• NTP Toxicology and Carcinogenesis Studies of 1-Trans-Delta(9)-Tetrahydrocannabinol (CAS No. 1972-08-3) in F344 Rats and B6C3F1 Mice (Gavage Studies)
• Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation
• Potentiation of Cannabinoid-Induced Cytotoxicity in Mantle Cell Lymphoma through Modulation of Ceramide Metabolism
• Potentiation of the antitumor activity of adriamycin against osteosarcoma by cannabinoid WIN-55,212-2
• Preparation and characterisation of biodegradable microparticles filled with THC and their antitumor efficacy on cancer cell lines
• Proapoptotic effect of endocannabinoids in prostate cancer cells
• Receptor-dependent and Receptor-independent Endocannabinoid Signaling: A Therapeutic Target for Regulation of Cancer Growth
• Regulation of nausea and vomiting by cannabinoids
• Structure-dependent inhibitory effects of synthetic cannabinoids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and skin tumour promotion in mice
• Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer
• Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling
• Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
• Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer
• The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids
• The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection
• The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway
• The combination of cannabidiol and Δ9-tetrahydrocannabinol enhances the anticancer effects of radiation in an orthotopic murine glioma model
• The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2
• The endocannabinoid system and cancer: therapeutic implication
• The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
• The Expression Level of CB1 and CB2 Receptors Determines Their Efficacy at Inducing Apoptosis in Astrocytomas
• The Medical Necessity for Medicinal Cannabis: Prospective, Observational Study Evaluating the Treatment in Cancer Patients on Supportive or Palliative Care
• The potential relevance of the endocannabinoid, 2- arachidonoylglycerol, in diffuse large B-cell lymphoma
• The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications
• The role of cannabinoids in the treatment of children with cancer
• The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
• The use of cannabinoids as anticancer agents
• Therapeutic use of Cannabis sativa on chemotherapy-induced nausea and vomiting among cancer patients: systematic review and meta-analysis
• Towards the use of cannabinoids as antitumour agents
• United States patent application publication for phytocannabinoids in the treatment of cancer

Cannabidiol (CBD)

• Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
• Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action
• Cannabidiol in Humans—The Quest for Therapeutic Targets
• Cannabidiol is a negative allosteric modulator of the type 1 cannabinoid receptor
• Identification of Psychoactive Degradants of Cannabidiol in Simulated Gastric and Physiological Fluid

CBDV

• Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression
• Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism

Cardiovascular

• Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion
• * An ultra-low dose of tetrahydrocannabinol provides cardioprotection
• A systematic review and meta-analysis of the haemodynamic effects of cannabidiol
• A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study
• Blood pressure regulation by endocannabinoids and their receptors
• * Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
• Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
• Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory and cell death signaling pathways in diabetic cardiomyopathy
• Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs
• Cannabinoids in experimental stroke: a systematic review and meta-analysis
• Cannabis use: signal of increasing risk of serious cardiovascular disorders
• Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta
• Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries
• *Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
• Endocannabinoids Acting at Cannabinoid-1 Receptors Regulate Cardiovascular Function in Hypertension
• Is the cardiovascular system a therapeutic target for cannabidiol?
• *Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors
• Oxyradical Stress, Endocannabinoids, and Atherosclerosis
• Role of Endocannabinoids and Cannabinoid-1 Receptors in Cerebrocortical Blood Flow Regulation
• *The effect of cannabidiol on ischemia/reperfusion-induced ventricular arrhythmias: the role of the adenosine A1 receptors
• * The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic–ischemic brain damage in mice is mediated by CB2 and adenosine receptors
• Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
• Vascular targets for cannabinoids: animal and human studies

CB1 Receptor

• Allosteric Modulation of the Cannabinoid CB1 Receptor
• Cannabidiol is a negative allosteric modulator of the type 1 cannabinoid receptor
• Cannabinoid CB1 receptor binding and acetylcholinesterase inhibitory activity of Sceletium tortuosum L.
• Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis
• Enhanced acetylcholine release in the hippocampus of cannabinoid
• Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid
• Immunohistochemical analysis of cannabinoid receptor 1 expression in steatotic rat livers
• Loss of Cannabinoid Receptor 1 Accelerates Intestinal Tumor Growth
• Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons

CB2 Receptor

• CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies
• Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor

Función Celular

• Cannabidiol is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19
• Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2 Levels
• Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana

Parálisis Cerebral

• * Cannabinoid mouth spray brought help to a severely spastic young man
• Marijuana: an effective antiepileptic treatment in partial epilepsy? A case report and review of the literature
• Survey Results of Pain Treatments in Adults with Cerebral Palsy

Encefalopatía Traumática Crónica (ETC)

• Acute upregulation of neuronal mitochondrial type-1 cannabinoid receptor and it’s role in metabolic defects and neuronal apoptosis after TBI
• * An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
• Cannabinoid agonist rescues learning and memory after a traumatic brain injury
• * Cannabinoids and brain injury: therapeutic implications
• CB1 and CB2 cannabinoid receptor antagonists prevent minocycline-induced neuroprotection following traumatic brain injury in mice
• Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet
• * Effect of Marijuana Use on Outcomes in Traumatic Brain Injury
• Endocannabinoids: A Promising Impact for Traumatic Brain Injury
• Endocannabinoids and traumatic brain injury
• Estradiol decreases cortical reactive astrogliosis after brain injury by a mechanism involving cannabinoid receptors
• Mechanisms of cannabidiol neuroprotection in hyopoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors
• Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist
• * The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
• The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors

Enfermedad Pulmonar Obstructiva Crónica (EPOC)

• β-Caryophyllene Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice through CB2 Receptor Activation and PPARγ Pathway
• * Acute effects of smoked marijuana and oral delta9-tetrahydrocannabinol on specific airway conductance in asthmatic subjects
• * Beneficial effects of cannabinoids (CB) in a murine model of allergen-induced airway inflammation: role of CB1/CB2 receptors
• Brochodiltor Effect of Δ1-Tetrahydrocannabinol
• Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury
• Cannabinoid effects on ventilation and breathlessness: a pilot study of efficacy and safety
• Cannabinoids, endocannabinoids, and related analogs in inflammation
• Cannabinoids inhibit cholinergic contraction in human airways through prejunctional CB1 receptors
• Cannabinoids Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells
• Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor
• * Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury
• * CB2 receptors regulate natural killer cells that limit allergic airway inflammation in a murine model of asthma
• Effects of cannabis on pulmonary structure, function and symptoms
• Human lung-resident macrophages express CB1 and CB2 receptors whose activation inhibits the release of angiogenic and lymphangiogenic factors
• Impact of cannabis, cannabinoids, and endocannabinoids in the lungs
• Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB₂) receptor activation
• Marijuana and chronic obstructive lung disease: a population-based study
• Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice
• * Preclinical assessment of novel therapeutics on the cough reflex: cannabinoid agonists as potential antitussives

Cognición

• Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis
• Keep off the grass Cannabis? Cognition and addiction

Colitis

• Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis
• Cannabinoids and gastrointestinal motility: Animal and human studies
• Cannabinoids and the gut: New developments and emerging concepts
• Cannabis finds its way into treatment of Crohn’s disease
• CBD in inflammatory bowel diseases: a brief overview
• CBD reduces intestinal inflammation through the control of neuroimmune axis
• Endocannabinoids and the gastrointestinal tract
• Hergenrather presents study of Crohn’s patients as a template for clinical research on Cannabis
• Low-dose cannabidiol is safe but not effective in the treatment for Crohn’s Disease, a randomized controlled trial
• Manipulation of the endocannabinoid system in colitis: A comprehensive review
• The effects of Delta-tetrahydrocannabinol and CBD alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
• Topical and systemic cannabidiol improves trinitrobenzene sulfonic acid colitis in mice

Cáncer de Colon

• Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells
• Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors
• Induction of Apoptosis by Cannabinoids in Prostate and Colon Cancer Cells Is Phosphatase Dependent
• The cannabinoid δ9-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells
• The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2
• The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells

Enfermedad de Crohn

• Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis
• Cannabinoids and gastrointestinal motility: Animal and human studies
• Cannabinoids and the gut: New developments and emerging concepts
• Cannabis Alleviates Symptoms Of Crohn’s Disease
• Cannabis for Inflammatory Bowel Disease
• Cannabis Finds Its Way into Treatment of Crohn’s Disease
• Cannabis induces a clinical response in patients with Crohn’s disease: a prospective placebo-controlled study
• CBD in inflammatory bowel diseases: a brief overview
• CBD reduces intestinal inflammation through the control of neuroimmune axis
• Endocannabinoids and the gastrointestinal tract
• Endocannabinoid system acts as a regulator of immune homeostasis in the gut
• Hergenrather presents study of Crohn’s patients as a template for clinical research on Cannabis
• Impact of cannabis treatment on the quality of life, weight and clinical disease activity in inflammatory bowel disease patients: a pilot prospective study
• Low-dose cannabidiol is safe but not effective in the treatment for Crohn’s Disease, a randomized controlled trial
• Manipulation of the endocannabinoid system in colitis: A comprehensive review
• Marijuana use patterns among patients with inflammatory bowel disease
• Protective effect of cannabidiol against cadmium hepatoxicity in rats
• The effects of Δ⁹-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
• Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats
• Topical and systemic cannabidiol improves trinitrobenzene sulfonic acid colitis in mice
• Treatment of Crohn’s Disease with Cannabis: An Observational Study

D9-Tetrahydrocannabinol (THC)

• A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
• Activity of cannabis in relation to its delta’-trans-tetrahydro-cannabinol content
• Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats
• BRONCHODILATOR EFFECT OF Δ1-TETRAHYDROCANNABINOL
• Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
• Cannabidiol Attenuates the Appetitive Effects of Δ9-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis
• Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
• D9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
• D9-Tetrahydrocannabinol Prevents Methamphetamine-Induced Neurotoxicity
• Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to delta9-tetrahydrocannabinol
• Fatty Acid Binding Proteins (FABPs) are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)
• Histone Modifications Are Associated with Delta (9)-tetrahydrocannabinol-Mediated Alterations in Antigen-Specific T Cell Responses
• Influence of Treatment of Tourette Syndrome with Δ9-Tetrahydrocannabinol (Δ9-THC) on Neuropsychological Performance
• Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity
• Opposite Effects of D-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
• The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin
• The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
• Treatment of Tourette-Syndrome with Δ9-Tetrahydrocannabinol (THC): a randomized crossover trial

Ácido Tetrahidrocannabinólico (THCA)

• Can You Pass the Acid Test? Critical Review and Novel Therapeutic Perspectives of D9-Tetrahydrocannabinolic Acid A
• Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity

Depresión

• Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects

Diabetes

• Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
• Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic β Cells
• Novel Study Reports Marijuana Users Have Better Blood Sugar Control
• Presence of functional cannabinoid receptors in human endocrine pancreas
• The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications
• The endocannabinoid system in obesity and type 2 diabetes

Interacciones de Medicamentos

• A Phase I, open-label, randomized, crossover study in three parallel groups to evaluate the effect of Rifampicin, Ketoconazole, and Omeprazole on the pharmacokinetics of THC/CBD oromucosal spray in healthy volunteers

Eczema

• *Adjuvant treatment of atopic eczema: assessment of an emollient containing N-palmitoylethanolamine (ATOPA study)
• *Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors
• *Cannabidiol—transdermal delivery and anti-inflammatory effect in a murine model
• *Cannabinoid agonists attenuate capsaicin‐induced responses in human skin
• Cannabinoid system in the skin – a possible target for future therapies in dermatology
• Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB 1 receptors
• *Efficacy and tolerance of the cream containing structured physiological lipids with endocannabinoids in the treatment of uremic pruritus: a preliminary study
• Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin
• The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities
• The role of cannabinoids in dermatology

Edema

• Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat

Émesis

• Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus
• Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation
• Regulation of nausea and vomiting by cannabinoids
• The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus
• The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3A Receptor-Mediated Currents in Xenopus laevis Oocytes

Sistema Endocanabinoide (SEC)

• Biphasic Effects of Cannabinoids on Acetylcholine Release in the Hippocampus: Site and Mechanism of Action
• Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
• Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor
• Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
• Cannabinoid pharmacology: the first 66 years
• Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain
• Cannabis, a complex plant: different compounds and different effects on individuals
• Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System
• Clinical endocannabinoid deficiency (CECD) revisited: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions
• Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
• Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to delta9-tetrahydrocannabinol
• Endocannabinoid Signaling Regulates Sleep Stability
• Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol
• Enhanced discriminative stimulus effects of 9-THC in the presence of cannabidiol and 8-OH-DPAT in rhesus monkeys
• Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: An Acute Slice Electrophysiological Study
• Evidence that the plant cannabinoid cannabigerol is a highly potent a2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist
• Fatty Acid Binding Proteins (FABPs) are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)
• Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system
• Modulating the endocannabinoid system in human health and disease: successes and failures
• Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol
• Targeting the endocannabinoid system with cannabinoid receptor agonists- pharmacological strategies and therapeutic possibilities
• The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin
• The Endocannabinoid-CB Receptor System: Importance for development and in pediatric disease
• The Endocannabinoid System as an Emerging Target of Pharmacotherapy
• The Endocannabinoid System, Cannabinoids, and Pain
• The endocannabinoid system in normal and pathological brain ageing
• The endogenous cannabinoid system and its role in nociceptive behavior
• The orphan receptor GPR55 is a novel cannabinoid receptor

Sistema Endocrino

• Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: An Acute Slice Electrophysiological Study
• Presence of functional cannabinoid receptors in human endocrine pancreas
• The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat

Epilepsia

• Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus
• Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome
• Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo
• Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model
• Cannabidiol for epilepsy: a new indication for an old drug
• Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders
• Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine
• Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression
• Cannabidivarin is anticonvulsant in mouse and rat
• Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism
• Cannabinoids for pediatric epilepsy? Up in smoke or real science?
• Cannabis-based products for pediatric epilepsy: An updated systematic review
• Cannabis and Epilepsy
• Cannabis, Cannabinoids and Tinnitus
• Cannabis In The Management And Treatment Of Seizures And Epilepsy: A Scientific Review
• CBD: A New Hope?
• CBD-enriched medical cannabis for intractable pediatric epilepsy; The current Israeli experience
• Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients
• Efficacy and adverse event profile of cannabidiol and medicinal cannabis for treatment-resistant epilepsy: Systematic review and meta-analysis
• Efficacy of cannabinoids in paediatric epilepsy
• Evidence for Cannabis and Cannabinoids for Epilepsy: A Systematic Review of Controlled and Observational Evidence
• On the application of cannabis in paediatrics and epileptology
• Parent use of cannabis for intractable pediatric epilepsy: Everyday empiricism and the boundaries of scientific medicine
• Pharmacological and Therapeutic Properties of Cannabidiol for Epilepsy
• Redistribution of CB1 Cannabinoid Receptors in the Acute and Chronic Phases of Pilocarpine-Induced Epilepsy
• Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy
• The case for assessing cannabidiol in epilepsy
• The case for medical marijuana in epilepsy
• The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy
• The Interplay between the Endocannabinoid System, Epilepsy and Cannabinoids
• Understanding Cannabinoids and Epilepsy
• Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials

Virus Epstein-Barr

• Delta-9 tetrahydrocannabinol (THC) inhibits lytic replication of gamma oncogenic herpesviruses in vitro

Fibromialgia

• Association of Herbal Cannabis Use With Negative Psychosocial Parameters in Patients With Fibromyalgia
• Clinical endocannabinoid deficiency (CECD) revisited: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions
• Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
• Marijuana Rated Most Effective for Treating Fibromyalgia

Fibrosis

• Cannabinoids and Cystic Fibrosis: A Novel Approach to Etiology and Therapy

Enfermedad Inflamatoria Intestinal

• Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis
• Cannabinoids and the gastrointestinal tract
• Cannabis Alleviates Symptoms Of Crohn’s Disease
• Cannabis Finds Its Way into Treatment of Crohn’s Disease
• Cannabis use amongst patients with inflammatory bowel disease
• Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism
• Marijuana Use Patterns Among Patients with Inflammatory Bowel Disease
• Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract
• The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
• Treatment of Crohn’s Disease with Cannabis: An Observational Study

General

• Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action
• Cannabinoids in health and disease
• Cannabis sativa: The Plant of the Thousand and One Molecules
• Future of Cannabis and Cannabinoids in Therapeutics
• Medical Marijuana: Clearing Away the Smoke
• Pharmacological actions and therapeutic uses of cannabis and cannabinoids
• Phytocannabinoids beyond the Cannabis plant – do they exist?
• Plant cannabinoids: a neglected pharmacological treasure trove
• Review on clinical studies with cannabis and cannabinoids 2010-2014
• Safety and Toxicology of Cannabinoids
• Therapeutic aspects of cannabis and cannabinoids
• Therapeutic Benefits of Cannabis: A Patient Survey
• The Therapeutic Potential of Cannabis and Cannabinoids

Glaucoma

• Cannabinoids and glaucoma
• Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity

Glioblastoma

• A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
• Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
• Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells
• Id-1 Is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target

Glioma

• A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma
• Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines
• Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells through a Multitarget Effect
• Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
• Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
• Cannabinoids Inhibit Glioma Cell Invasion by Down-regulating Matrix Metalloproteinase-2 Expression
• Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas
• Δ9-Tetrahydrocannabinol induces apoptosis in C6 glioma cells
• Inhibition of Glioma Growth in Vivo by Selective Activation of the CB2 Cannabinoid Receptor

Tiroiditis de Hashimoto/Enfermedad de Graves

• *Cannabinoids decrease the th17 inflammatory autoimmune phenotype
• *Neuroprotective activity of cannabinoid receptor-2 against oxidative stress and apoptosis in rat pups having experimentally-induced congenital hypothyroidism
• *The CB1 receptor is required for the establishment of the hyperlocomotor phenotype in developmentally-induced hypothyroidism in mice

Virus del Herpes

• Delta-9 tetrahydrocannabinol (THC) inhibits lytic replication of gamma oncogenic herpesviruses in vitro
• The effect of delta-9-tetrahydrocannabinol on herpes simplex virus replication
• Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside
• Cannabis May Help Combat Cancer-causing Herpes Viruses
• Effects of Cannabinoids on T-cell Function and Resistance to Infection
• Suppressive effect of delta-9-tetrahydrocannabinol on herpes simplex virus infectivity in vitro
• Delta-9 tetrahydrocannabinol (THC) inhibits lytic replication of gamma oncogenic herpesviruses in vitro

VIH

• Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins

Virus del Papiloma Humano (VPH)

• Short-term efficacy of CBD-enriched hemp oil in girls with dysautonomic syndrome after human papillomavirus vaccination

Enfermedad de Huntington

• Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington’s disease transgenic mice
• Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity

Función Inmune

• Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis
• Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties
• Cannabinoids and the immune system
• CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies
• D9-Tetrahydrocannabinol-Induced Apoptosis in the Thymus and Spleen as a Mechanism of Immunosuppression in Vitro and in Vivo
• Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
• Histone Modifications Are Associated with Delta (9)-tetrahydrocannabinol-Mediated Alterations in Antigen-Specific T Cell Responses

Desarrollo Infantil

• Endocannabinoids, feeding and suckling – from our perspective
• Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage
• The Endocannabinoid-CB Receptor System: Importance for development and in pediatric disease

Inflamación

• Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol – studies in BV-2 microglia and encephalitogenic T cells
• Anti-Inflammatory Role of Cannabidiol and O-1602 in Cerulein-Induced Acute Pancreatitis in Mice
• Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
• Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
• Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors
• Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
• Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis
• Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study
• Cannabinoid CB2 receptors in human brain inflammation
• Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation
• Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
• Cannabinoids in models of chronic inflammatory conditions
• Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability
• Cannabinoids Reduce Markers of Inflammation and Fibrosis in Pancreatic Stellate Cells
• Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
• Cannabinomimetic Control of Mast Cell Mediator Release: New Perspective in Chronic Inflammation
• Clinical Implications for Cannabinoid Use in the Rheumatic Diseases
• Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa
• Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
• Oxyradical Stress, Endocannabinoids, and Atherosclerosis
• Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol
• The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis

Enfermedad Inflamatoria Intestinal

• A clinical study showed that cannabis produces significant clinical benefits in patients with Crohn’s disease, including a reduction in pain sensation, nausea relief and reduce the feeling of unpleasantness.
• Clinical endocannabinoid deficiency (CECD) revisited: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions
• Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes

Isquemia

• Activation of Cannabinoid CB2 Receptor–Mediated AMPK-CREB Pathway Reduces Cerebral Ischemic Injury
• Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion
• Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
• Effects of Cannabidiol and Hypothermia on Short-Term Brain Damage in New-Born Piglets after Acute Hypoxia-Ischemia
• HU­211, a Novel Noncompetitive N­Methyl­D­Aspartate Antagonist, Improves Neurological Deficit and Reduces Infarct Volume After Reversible Focal Cerebral Ischemia in the Rat
• Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT1A and CB2 receptors
• The Cannabinoid Agonist Win55212 Reduces Brain Damage in an In Vivo Model of Hypoxic-Ischemic Encephalopathy in Newborn Rats
• Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats
• Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
• Update on the Role of Cannabinoid Receptors after Ischemic Stroke

Riñón

• Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death

Enfermedad de Krabbe

• Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
• CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies
• Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor
• Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection
• The endocannabinoid system as a target for the treatment of neurodegenerative disease
• The Endocannabinoid System Is Dysregulated in Multiple Sclerosis and in Experimental Autoimmune Encephalomyelitis
• Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis

Leucemia

• *γ-Irradiation Enhances Apoptosis Induced by Cannabidiol, a Non-psychotropic Cannabinoid, in Cultured HL-60 Myeloblastic Leukemia Cells
• Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression
• Cannabidiol for the Prevention of Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation: Results of a Phase II Study
• Cannabinoids induce incomplete maturation of cultured human leukemia cells
• *Cannabinoids: potential anticancer agents
• *Cannabis-induced cytotoxicity in leukemia cell lines: the role of the cannabinoid receptors and the MAPK pathway
• Cannabis extract treatment for terminal acute lymphoblastic leukemia with a Philadelphia chromosome mutation
• D9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria
• Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns
• Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedule
• *Enhancing the in vitro cytotoxic activity of Delta9-tetrahydrocannabinol in leukemic cells through a combinatorial approach

Hígado

• Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice
• Endocannabinoids in Liver Disease
• Exogenous hepatitis B virus envelope proteins induce endoplasmic reticulum stress: involvement of cannabinoid axis in liver cancer cells
• Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol

Cáncer de Pulmón

• Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis
• Cannabinoids for Cancer Treatment: Progress and Promise
• COX-2 and PPAR-g Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells
• Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
• Marijuana Use and the Risk of Lung and Upper Aerodigestive Tract Cancers: Results of a Population-Based Case-Control Study

Lupus

• Cannabinoids as Novel Anti-Inflammatory Drugs
• The analgesic potential of cannabinoids
• Endogenous Interleukin-1 Receptor Antagonist Mediates Anti-Inflammatory and Neuroprotective Actions of Cannabinoids in Neurons and Glia

Enfermedad de Lyme

• Antibacterial activity of Δ9-­tetrahydrocannabinol and cannabidiol
• Antibacterial Cannabinoids from Cannabis sativa: A Structure-Activity Study
• Antimicrobial Activity of Cannabis sativa L.
• Extraction of cannabinoids from cannabis sativa L plant and its potential antimicrobial activity
• In vitro antibacterial activity of Cannabis sativa leaf extracts to some selective pathogenicbacterial strains

Degeneración Macular

• Mediation of Cannabidiol anti-inflammation in the Retina by Equilibrative Nucleoside Transporter and A2A Adenosine Receptor*
• Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes
• Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity

Memoria

• Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study
• Non-acute (residual) neurocognitive effects of cannabis Use: A meta-analytic study
• On Disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment
• The cannabinoid receptor agonist WIN 55-212-2 facilitates the extinction of contextual fear memory and spatial memory in rats
• Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons

Enfermedad Mental

• Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats
• β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice
• Brain CB2 Receptors: Implications for Neuropsychiatric Disorders
• Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug
• Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances
• Cannabidiol as a potential treatment for psychosis
• Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
• Cannabidiol, neuroprotection and neuropsychiatric disorders
• Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice
• Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: Additional evidence
• Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential
• Cannabis as a substitute for alcohol and other drugs
• CB1 cannabinoid receptor stimulation during adolescence impairs the maturation of GABA function in the adult rat prefrontal cortex
• Distinct Neurobehavioural Effects of Cannabidiol in Transmembrane Domain Neuregulin 1 Mutant Mice
• Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis
• Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain
• Influence of Treatment of Tourette Syndrome with Δ9-Tetrahydrocannabinol (Δ9-THC) on Neuropsychological Performance
• Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood
• Long term marijuana users seeking medical cannabis in California (2001–2007): demographics, social characteristics, patterns of cannabis and other drug use of 4117 applicants
• Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders
• Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report – ResearchGate
• Opposite Effects of D-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
• The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system
• The Development of Cannabidiol as a Psychiatric Therapeutic: A Review of Its Antipsychotic Efficacy and Possible Underlying Pharmacodynamic Mechanisms
• The endocannabinoid system and emotional Processing: A pharmacological fMRI study with Δ9-tetrahydrocannabinol
• Therapeutical use of the cannabinoids in psychiatry

Migraña

• Activation of CB2 receptors as a potential therapeutic target for migraine: evaluation in an animal model
• Clinical Endocannabinoid Deficiency (CECD): Can this Concept Explain Therapeutic Benefits of Cannabis in Migraine, Fibromyalgia, Irritable Bowel Syndrome and other Treatment-Resistant Conditions
• Clinical endocannabinoid deficiency (CECD) revisited: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions
• Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache: What a Long Strange Trip It’s Been
• Effects of anandamide in migraine: data from an animal model
• Endocannabinoids in the Brainstem Modulate Dural Trigeminovascular Nociceptive Traffic via CB1 and “Triptan” Receptors: Implications in Migraine
• The endocannabinoid system and migraine

Mitocondria 

• Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis
• Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2 Levels
• Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system

Mutación Genética MTHFR

• Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol – studies in BV-2 microglia and encephalitogenic T cells
• Cannabidiol affects the expression of genes involved in zinc homeostasis in BV-2 microglial cells
• Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure
• Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis
• Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT1A and CB2 receptors

Esclerosis Multiple

• A cannabinoid agonist interferes with the progression of a chronic model of multiple sclerosis by downregulating adhesion molecules
• Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors
• Cannabinoid Modulation of Neuroinflammatory Disorders
• Cannabinoids and multiple sclerosis
• Cannabinoids control spasticity and tremor in a multiple sclerosis model
• Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial
• Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up
• Cannabinoids in the management of spasticity associated with multiple sclerosis
• Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
• CBD provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors
• Clinical experiences with cannabinoids in spasticity management in multiple sclerosis
• Effects of cannabis on cognitive function in patients with multiple sclerosis
• Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study
• Oromucosal delta9-THC/CBD for neuropathic pain associated with multiple sclerosis
• Psychopathological and cognitive effects of therapeutic cannabinoids in multiple sclerosis: a double-blind, placebo controlled, crossover study
• Sativex in the Management of Multiple Sclerosis-Related Spasticity: Role of the Corticospinal Modulation
• Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial
• Symptomatic therapy in multiple sclerosis: the role of cannabinoids in treating spasticity
• THC:CBD Observational Study Data: Evolution of Resistant MS Spasticity and Associated Symptoms
• The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection
• The effect of cannabis on tremor in patients with multiple sclerosis
• The Endocannabinoid System Is Dysregulated in Multiple Sclerosis and in Experimental Autoimmune Encephalomyelitis
• Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis
• Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review

Instituto Nacional sobre el Abuso de Drogas E.E.U.U.

• NIDA Research on the Therapeutic Benefits of Cannabis and Cannabinoids

Nausea

• Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus
• Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation
• Cannabinoid Regulation of Acute and Anticipatory Nausea
• Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews
• Regulation of nausea and vomiting by cannabinoids

Sistema Nervioso

• Cannabinoid–Dopamine Interaction in the Pathophysiology and Treatment of CNS Disorders
• Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor
• Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
• “The Therapeutic Potential of Cannabinoids for Movement
  Disorders | Nervous System”

Neuroprotector y Neurogenerativo

• Activation of Type 1 Cannabinoid Receptor (CB1R) Promotes Neurogenesis in Murine Subventricular Zone Cell Cultures
• Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
• Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid
• Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice
• Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
• Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
• Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
• Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
• Cannabinoids: Well-Suited Candidates for the Treatment of Perinatal Brain Injury
• CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice
• CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity
• Comparison of Cannabidiol, Antioxidants, and Diuretics in Reversing Binge Ethanol-Induced Neurotoxicity
• Endocannabinoid Signaling In Neurotoxicity And Neuroprotection
• Endocannabinoids and traumatic brain injury
• Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection
• Long-­term behavioral and biochemical effects of an ultra-­low dose of Δ9-­tetrahydrocannabinol (THC): neuroprotection and ERK signaling
• Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity
• Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity
• Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes
• Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
• Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity
• Nonpsychoactive Cannabidiol Prevents Prion Accumulation and Protects Neurons against Prion Toxicity
• Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist
• Prospects for cannabinoid therapies in basal ganglia disorders
• Protective effects of Δ9-tetrahydrocannabinol against N-methyl-D-aspartate-induced AF5 cell death
• Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity
• The Cannabinoid WIN55212-2 Promotes Neural Repair After Neonatal Hypoxia–Ischemia
• The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection
• The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K Akt mTORC1 BDNF pathway
• The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
• The endocannabinoid system as a target for the treatment of neurodegenerative disease
• The endocannabinoid system in normal and pathological brain ageing
• Δ9-Tetrahydrocannabinol Prevents Methamphetamine-Induced Neurotoxicity

Linfoma no Hodgkin

• Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: Growth inhibition by receptor activation

Nutrición

• An Increase in the Omega-6-Omega-3 Fatty Acid Ratio Increases the Risk for Obesity
• The Composition of Hemp Seed Oil and Its Potential as an Important Source of Nutrition

Obesidad

• An Increase in the Omega-6-Omega-3 Fatty Acid Ratio Increases the Risk for Obesity
• Cannabinoid receptor 2 as anti-obesity target: inflammation, fat storage and browning modulation
• Pathophysiological role of host microbiota in the development of obesity
• The cannabinoid Δ9-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity

Obsessive Compulsive Disorder (OCD)

• Facilitation of CB1 receptor-mediated neurotransmission decreases marble burying

Optic Function

• Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys

Organ Transplants

• Marijuana Use in Potential Liver Transplant Candidates

Pain

• Amygdala activity contributes to the dissociative effect of cannabis on pain perception
• Assessing efficacy of non-opioid analgesics in experimental pain models in healthy volunteers- an updated review
• Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy
• Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint
• Cannabinoid receptors and pain
• Cannabinoids delivery systems based on supramolecular inclusion complexes and polymeric nanocapsules for treatment of neuropathic pain
• Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials
• Cannabinoids in the management of difficult to treat pain
• Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
• Cannabis for the Management of Pain: Assessment of Safety Study (COMPASS)
• Clinical Implications for Cannabinoid Use in the Rheumatic Diseases
• Impact of Marijuana on Children and Adolescents
• Injury, Pain, and Prescription Opioid Use Among Former National Football League (NFL) Players
• Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
• Prescribing cannabis for harm reduction
• Role of Cannabinoids in Pain Management
• Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes
• Smoked cannabis for chronic neuropathic pain: a randomized controlled trial
• Stable dose cannabinoid medicine GW
• Survey Results of Pain Treatments in Adults with Cerebral Palsy
• Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine
• Targeting CB2 receptors and the endocannabinoid system for the treatment of pain
• The Endocannabinoid System, Cannabinoids, and Pain
• The endogenous cannabinoid system and its role in nociceptive behavior
• The Pharmacologic and Clinical Effects of Medical Cannabis
• Use of prescription pain medications among medical cannabis patients: comparisons of pain levels, functioning, and patterns of alcohol and other drug use
• δ-Ctenitoxin-Pn1a, a Peptide from Phoneutria nigriventer Spider Venom, Shows Antinociceptive Effect Involving Opioid and Cannabinoid Systems, in Rats

Pancreatitis

• Anti-Inflammatory Role of Cannabidiol and O-1602 in Cerulein-Induced Acute Pancreatitis in Mice
• Cannabinoids Ameliorate Pain and Reduce Disease Pathology in Cerulein-Induced Acute Pancreatitis
• Cannabinoids Reduce Markers of Inflammation and Fibrosis in Pancreatic Stellate Cells

Parkinson’s

• A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson’s disease
• Effects of cannabidiol in the treatment of patients with Parkinson’s disease: An exploratory double-blind trial
• Effects of cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic acid and cannabidiol in MPP+ affected murine mesencephalic cultures
• Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson’s disease
• Increased cannabinoid CB1 receptor binding and activation of GTP‐binding proteins in the basal ganglia of patients with Parkinson’s syndrome and of MPTP‐treated marmosets
• Potential of the cannabinoid CB2 receptor as a pharmacological target against inflammation in Parkinson’s disease
• Promising cannabinoid-based therapies for Parkinson’s disease: motor symptoms to neuroprotection
• Self-Reported Efficacy of Cannabis and Other Complementary Medicine Modalities by Parkinson’s Disease Patients in Colorado
• Survey on Cannabis Use in Parkinson’s Disease: Subjective Improvement of Motor Symptoms
• The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1-2 phosphorylation in 6-OHDA-lesioned rats
• The influence of cannabinoids on generic traits of neurodegeneration

Patents

• Formulation And Method For Increasing Oral Bioavailability Of Drugs
• United States patent application publication for phytocannabinoids in the treatment of cancer
• United States patent on cannabinoids as antioxidants and neuroprotectants

Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)

• Cannabinoids as novel anti-inflammatory drugs
• Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression
• CB2 cannabinoid receptor agonist, JWH-015 triggers apoptosis in immune cells: Potential role for CB2 selective ligands as immunosuppressive agents

Pets

• Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

Pharmacokinetics

• Formulation And Method For Increasing Oral Bioavailability Of Drugs
• Human Cannabinoid Pharmacokinetics

Polycystic Ovary Syndrome (PCOS)

• Activation of cannabinoid CB1 receptors induces glucose intolerance in rats
• Cannabinoid Receptor 1 Gene Polymorphisms and Nonalcoholic Fatty Liver Disease in Women with Polycystic Ovary Syndrome and in Healthy Controls
• *Decreased expression of fatty acid amide hydrolase in women with polycystic ovary syndrome
• *Effects of cannabinoid antagonist-induced weight loss in polycystic ovarian syndrome (PCOS) patients
• Endocannabinoid receptor blockade reduces alanine aminotransferase in polycystic ovary syndrome independent of weight loss
• *Endocannabinoid system activation may be associated with insulin resistance in women with polycystic ovary syndrome
• Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
• The endocannabinoid pathway and the female reproductive organs

Post Traumatic Stress Disorder (PTSD)

• Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing
• Changes of endocannabinoid plasma levels following type I trauma: A prospective pilot study
• Elevated Brain Cannabinoid CB1 Receptor Availability in Posttraumatic Stress Disorder- A Positron Emission Tomography Study
• On Disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment
• PTSD Symptom Reports of Patients Evaluated for the New Mexico Medical Cannabis Program

Potential of whole plant vs. single compound model

• A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol
• Activity of cannabis in relation to its delta’-trans-tetrahydro-cannabinol content
• An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity
• Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
• Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts
• Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
• Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects

Pregnancy

• Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines
• Fetal Alcohol Spectrum Disorder: Potential Role of Endocannabinoids Signaling
• Lasting impacts of prenatal cannabis exposure and the role of endogenous cannabinoids in the developing brain
• Multiple Roles for the Endocannabinoid System During the Earliest Stages of Life: Pre- and Postnatal Development
• The Endocannabinoid-CB Receptor System: Importance for development and in pediatric disease

Prostate Cancer

• Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK12 Leading to G1 Cell Cycle Arrest
• Cannabinoid receptor as a novel target for the treatment of prostate cancer
• Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R( þ )-Methanandamide and JWH-015: Involvement of CB2
• Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms
• Proapoptotic effect of endocannabinoids in prostate cancer cells
• The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications

Psoriasis

• Cannabinoids inhibit human keratinocyte proliferation through a non-CB1-CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis

Psychiatry

• CBD Decreases Opioid and other addictions, such as Heroin – mouse studies. Cannabidiol decreases the “drug-seeking behavior”. The opposite of a “gateway drug”.

Pulmonary Function

• Association Between Marijuana Exposure and Pulmonary Function Over 20 Years
• Bronchodilator Effect Of Δ1-Tetrahydrocannabinol
• Cannabinoid effects on ventilation and breathlessness: a pilot study of efficacy and safety
• Does smoking marijuana increase the risk of chronic obstructive pulmonary disease
• Effects of Marijuana Smoking on the Lung
• Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation
• Marijuana and chronic obstructive lung disease: a population-based study
• Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice
• The effects of marijuana exposure on expiratory airflow. A study of adults who participated in the U.S. National Health and Nutrition Examination Study

Restless Leg Syndrome

• Cannabis for restless legs syndrome: a report of six patients
• *Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine

Rheumatoid Arthritis

• Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis
• The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
• Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
• Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis
• A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis
• Cannabinoids: novel therapies for arthritis?
• Cannabinoids as novel anti-inflammatory drugs

Schizophrenia

• A clinical comparison of schizophrenia with and without pre-onset cannabis use disorder: a retrospective cohort study using categorical and dimensional approaches
• Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
• Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice
• Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis
• Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain

Sickle-cell Disease

• Cannabis use in sickle cell disease: a questionnaire study
• Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids

Sjögren’s Syndrome

• Cannabinoids as novel anti-inflammatory drugs
• The analgesic potential of cannabinoids

Skeletal System

• Activation of Cannabinoid Receptor 2 Enhances Osteogenic Differentiation of Bone Marrow Derived Mesenchymal Stem Cells
• Cannabinoid receptors and the regulation of bone mass
• Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro
• Effects of deleting cannabinoid receptor-2 on mechanical and material properties of cortical and trabecular bone
• Peripheral cannabinoid receptor, CB2, regulates bone mass
• Protective Effects of Cannabidiol on Lesion-Induced Intervertebral Disc Degeneration
• Role of cannabinoids in the regulation of bone remodeling
• The Role Of Type 2 Cannabinoid Receptor In Bone Metabolism

Skin

• Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
• The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities

Sleep Disorders

• A Longitudinal Study of Prenatal Marijuana Use
• A Pilot Study into the Effects of the CB1 Cannabinoid Receptor Agonist WIN55,212-2 or the Antagonist-Inverse Agonist AM251 on Sleep in Rats
• Administration of URB597, Oleoylethanolamide or Palmitoylethanolamide Increases Waking and Dopamine in Rats
• Around‐the‐Clock Oral THC Effects on Sleep in Male Chronic Daily Cannabis Smokers
• Effect of cannabis and certain of its constituents on pentobarbitone sleeping time and phenazone metabolism
• Effect of Δ-9-Tetrahydrocannabinol and Cannabidiol on Nocturnal Sleep and Early-Morning Behavior in Young Adults
• Endocannabinoid Signaling Regulates Sleep Stability
• Intrahippocampal administration of anandamide increases REM sleep
• Modulation of Sleep-Wake Cycles in Mice and Rats with Cannabinoids
• Proof of concept trial of dronabinol in obstructive sleep apnea

Spasticity

• A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex®), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis
• Cannabinoids in the management of spasticity associated with multiple sclerosis
• Clinical experiences with cannabinoids in spasticity management in multiple sclerosis
• Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study
• Sativex in the Management of Multiple Sclerosis-Related Spasticity: Role of the Corticospinal Modulation
• Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial
• Symptomatic therapy in multiple sclerosis: the role of cannabinoids in treating spasticity
• Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review

Spinal Cord Disease

• A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms
• A survey of cannabis (marijuana) use and self-reported benefit in men with chronic prostatitis/chronic pelvic pain syndrome

Spinal Cord Injuries

• Early Endogenous Activation of CB1 and CB2 Receptors after Spinal Cord Injury Is a Protective Response Involved in Spontaneous Recovery
• Treatments for Chronic Pain in Persons With Spinal Cord Injury: A Survey Study

Sports Related

• Activation of Cannabinoid CB2 Receptor–Mediated AMPK-CREB Pathway Reduces Cerebral Ischemic Injury
• Activation of cortical type 2 cannabinoid receptors ameliorates ischemic brain injury
• Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion
• Acute upregulation of neuronal mitochondrial type-1 cannabinoid receptor and it’s role in metabolic defects and neuronal apoptosis after TBI
• Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
• Cannabinoid agonist rescues learning and memory after a traumatic brain injury
• Cannabinoid receptors and the regulation of bone mass
• Cannabis Responsive Head Injury Induced Mutiple Disabilities: A Case Report
• CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice
• Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet
• Effects of Cannabidiol and Hypothermia on Short-Term Brain Damage in New-Born Piglets after Acute Hypoxia-Ischemia
• Endocannabinoids and traumatic brain injury
• Estradiol Decreases Cortical Reactive Astrogliosis after Brain Injury by a Mechanism Involving Cannabinoid Receptors
• HU­211, a Novel Noncompetitive N­Methyl­D­Aspartate Antagonist, Improves Neurological Deficit and Reduces
• Infarct Volume After Reversible Focal Cerebral Ischemia in the Rat
• Injury, Pain, and Prescription Opioid Use Among Former National Football League (NFL) Players
• Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT1A and CB2 receptors
• Peripheral cannabinoid receptor, CB2, regulates bone mass
• Role of cannabinoids in the regulation of bone remodeling
• The Cannabinoid Agonist Win55212 Reduces Brain Damage in an In Vivo Model of Hypoxic-Ischemic Encephalopathy in Newborn Rats
• The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
• The Role Of Type 2 Cannabinoid Receptor In Bone Metabolism
• Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
• Tissue Engineering of Cartilage; Can Cannabinoids Help?
• Update on the Role of Cannabinoid Receptors after Ischemic Stroke

Staph (Infections)

• Is Cannabis the Solution to Antibiotic-Resistant Staph and Superbug Crisis?

Stroke

• Cannabinoids in experimental stroke: a systematic review and meta-analysis
• Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
• Update on the Role of Cannabinoid Receptors after Ischemic Stroke

Super Canal Dehiscence

• Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system

Thyroid

• Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions
• *Expression of the CB1 and CB2 receptor messenger RNAs during embryonic development in the rat
• Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid
• *Neuroprotective activity of cannabinoid receptor-2 against oxidative stress and apoptosis in rat pups having experimentally-induced congenital hypothyroidism
• The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance
• Type 1 Cannabinoid Receptor-Containing Axons Innervate Hypophysiotropic Thyrotropin-Releasing Hormone-Synthesizing Neurons

Tourette’s Syndrome

• *Cannabinoids for Tourette’s Syndrome (Review)
• Cannabinoids: possible role in patho-physiology and therapy of Gilles de la Tourette syndrome
• Cannabinoids reduce symptoms of Tourette’s syndrome
• *Delta 9-Tetrahydrocannabinol (THC) is Effective in the Treatment of Tics in Tourette Syndrome: a 6-Week Randomized Trial
• Influence of Treatment of Tourette Syndrome with Δ9-Tetrahydrocannabinol (Δ9-THC) on Neuropsychological Performance
• *Preliminary Evidence on Cannabis Effectiveness and Tolerability for Adults With Tourette Syndrome
• Significant Tic Reduction in An Otherwise Treatment-Resistant Patient with Gilles de la Tourette Syndrome Following Treatment with Nabiximols
• Speechlessness in Gilles de la Tourette Syndrome: Cannabis-Based Medicines Improve Severe Vocal Blocking Tics in Two Patients
• Treatment of Tourette syndrome with cannabinoids (Review)
• *Treatment of Tourette-Syndrome with Δ9-Tetrahydrocannabinol (THC): a randomized crossover trial

Traumatic Brain Injury (TBI)

• Acute upregulation of neuronal mitochondrial type-1 cannabinoid receptor and it’s role in metabolic defects and neuronal apoptosis after TBI
• An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
• Cannabinoid agonist rescues learning and memory after a traumatic brain injury
• CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice
• Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet
• Endocannabinoids and traumatic brain injury
• Estradiol Decreases Cortical Reactive Astrogliosis after Brain Injury by a Mechanism Involving Cannabinoid Receptors
• Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist

Tumors

• Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines
• The antitumor activity of plant-derived non-psychoactive cannabinoids

West Syndrome

• Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy